Title : RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells.

Pub. Date : 2021 Jun 1

PMID : 34074709






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Angiotensin II (AngII) stimulates adrenocortical cells to produce aldosterone, a master regulator of blood pressure. Aldosterone angiotensinogen Homo sapiens
2 Angiotensin II (AngII) stimulates adrenocortical cells to produce aldosterone, a master regulator of blood pressure. Aldosterone angiotensinogen Homo sapiens
3 Using a candidate screen, we identified a subset of RNA-binding protein and RNA decay factors that activate or repress AngII-stimulated aldosterone production. Aldosterone angiotensinogen Homo sapiens
4 BTG2 was induced in response to AngII stimulation and promoted the repression of mRNAs encoding pro-steroidogenic factors indicating the existence of an incoherent feedforward loop controlling aldosterone homeostasis. Aldosterone angiotensinogen Homo sapiens