Title : Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug-Drug Interaction in Healthy Volunteers.

Pub. Date : 2021 May 24

PMID : 34073662






1 Functional Relationships(s)
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1 These results suggested that 1beta-OH-DCA/ToDCA in spot urine is a promising convenient, non-invasive, sensitive, and relatively quickly responsive endogenous biomarker that can be used for CYP3A inhibition-based drug-drug interaction in clinical studies. 1beta-oh-dca cytochrome P450 family 3 subfamily A member 4 Homo sapiens