Title : Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug-Drug Interaction in Healthy Volunteers.

Pub. Date : 2021 May 24

PMID : 34073662






2 Functional Relationships(s)
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1 In this study, we aimed to evaluate the utility of endogenous 1beta-hydroxy-deoxycholic acid/total deoxycholic acid ratio (1beta-OH-DCA/ToDCA) in spot urine as a surrogate marker of cytochrome P450 3A (CYP3A) activity in the assessment inhibition-based drug-drug interactions in healthy volunteers. 1beta-hydroxy-deoxycholic acid cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In this study, we aimed to evaluate the utility of endogenous 1beta-hydroxy-deoxycholic acid/total deoxycholic acid ratio (1beta-OH-DCA/ToDCA) in spot urine as a surrogate marker of cytochrome P450 3A (CYP3A) activity in the assessment inhibition-based drug-drug interactions in healthy volunteers. 1beta-hydroxy-deoxycholic acid cytochrome P450 family 3 subfamily A member 4 Homo sapiens