Title : Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1β Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation.

Pub. Date : 2021 May 11

PMID : 34064821






1 Functional Relationships(s)
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1 The enzymes 5-lipoxygenase and 12-lipoxygenase, which catalyze the synthesis of BLT1/2 ligands (LTB4, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), and 12-hydroxyheptadecatreinoic acid (12-HHT)), were also critically associated with the stimulation of NLRP3 and IL-1beta synthesis. Leukotriene B4 interleukin 1 alpha Homo sapiens