Pub. Date : 2021
PMID : 34054811
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here, by two models of a primary rat breast cancer and cell co-culture, we demonstrated that valproic acid (VPA) and its derivative (HPTA) are effective immune activators for RT to inhibit tumor growth by inducing myeloid-derived macrophages and polarizing them toward the M1 phenotype, thus elevate the expression of cytokines such as IL-12, IL-6, IFN-gamma and TNF-alpha during the early stage of the combination treatment. | Valproic Acid | tumor necrosis factor | Rattus norvegicus |
2 | Here, by two models of a primary rat breast cancer and cell co-culture, we demonstrated that valproic acid (VPA) and its derivative (HPTA) are effective immune activators for RT to inhibit tumor growth by inducing myeloid-derived macrophages and polarizing them toward the M1 phenotype, thus elevate the expression of cytokines such as IL-12, IL-6, IFN-gamma and TNF-alpha during the early stage of the combination treatment. | Valproic Acid | tumor necrosis factor | Rattus norvegicus |