Title : Salusin-β Mediates High Glucose-Induced Inflammation and Apoptosis in Retinal Capillary Endothelial Cells via a ROS-Dependent Pathway in Diabetic Retinopathy.

Pub. Date : 2021

PMID : 34054302






2 Functional Relationships(s)
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1 Salusin-beta exacerbated inflammation and apoptosis, upregulated intracellular ROS production in HG-induced HRECs, and activated ROS-dependent JNK and p38 MAPK signalling, while knockdown of salusin-beta suppressed these effects. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens
2 Conclusion: Our findings indicate that salusin-beta can promote inflammation and apoptosis via ROS-dependent JNK and p38 MAPK signalling in HG-induced HRECs and could be a therapeutic target for DR. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens