Title : The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p.

Pub. Date : 2021 Oct

PMID : 34052462






2 Functional Relationships(s)
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1 CONCLUSION: We show for the first time that tofacitinib suppresses the expression level of JAK1/TNF-alpha/IL-6 by upregulating miR-149-5p level. tofacitinib tumor necrosis factor Mus musculus
2 Our findings revealed the functional association between proinflammatory JAK1/TNF-alpha/IL-6 signaling and ACs development and highlight the therapeutic potential of tofacitinib in OA. tofacitinib tumor necrosis factor Mus musculus