Title : Downregulation of NK cell activities in Apolipoprotein C-III-induced hyperlipidemia resulting from lipid-induced metabolic reprogramming and crosstalk with lipid-laden dendritic cells.

Pub. Date : 2021 Jul

PMID : 34051224






1 Functional Relationships(s)
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1 Inhibition of PPAR or CPT1alpha only partly reversed the IFN-gamma production of Apoc3TG-NK cells, but completely restored IFN-gamma secretion by palmitic acid-treated NK cells ex vivo, indicating that other factors contributed to the Apoc3TG-NK cell downregulation. Palmitic Acid peroxisome proliferator activated receptor alpha Mus musculus