Title : Chronic valproic acid administration enhances oxidative stress, upregulates IL6 and downregulates Nrf2, Glut1 and Glut4 in rat's liver and brain.

Pub. Date : 2021 Jul 7

PMID : 34050116






3 Functional Relationships(s)
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1 Chronic valproic acid administration enhances oxidative stress, upregulates IL6 and downregulates Nrf2, Glut1 and Glut4 in rat"s liver and brain. Valproic Acid solute carrier family 2 member 4 Rattus norvegicus
2 We found that administration of VPA (200 mg and 400 mg) caused a significant decrease in the Glut1 and Glut4 expression in different tissues in a dose- and time-dependent manner (P < 0.01). Valproic Acid solute carrier family 2 member 4 Rattus norvegicus
3 The results suggest that increasing the dose and time of VPA therapy downregulates Glut1 and Glut4 in the liver and brain which may impair glucose uptake in these tissues. Valproic Acid solute carrier family 2 member 4 Rattus norvegicus