Pub. Date : 2021 Dec 1
PMID : 34047175
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c-acute myeloid leukemia. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 2 | Here, we demonstrate that PML is required to initiate RA-driven NPM-1c degradation, P53 activation and cell death. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 3 | Mechanistically, RA enhances PML basal expression through inhibition of activated Pin1, prior to NPM-1c degradation. | Tretinoin | PML nuclear body scaffold | Homo sapiens |