Title : Characterization of halothane oxidation by hepatic microsomes and purified cytochromes P-450 using a gas chromatographic mass spectrometric assay.

Pub. Date : 1988 Aug

PMID : 3404442






3 Functional Relationships(s)
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Protein Name
Organism
1 The cytochrome P-450 in microsomes from a single human subject metabolized halothane at a rate comparable to that found in microsomes from phenobarbital- and imidazole-pretreated rabbits. Halothane cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits. Halothane cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits. Halothane cytochrome P450 family 4 subfamily F member 3 Homo sapiens