Pub. Date : 2021
PMID : 34040527
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both EPR and LCMS studies confirmed a significant increase in the ROS production in the NQO2 overexpressing cells due to the fast reduction of quinone into quinol that can re-oxidize to form superoxide radicals. | Hydroquinones | N-ribosyldihydronicotinamide:quinone reductase 2 | Homo sapiens |
| 2 | Whereas NQO2 inhibition decreases the amount of superoxide in the first case by decreasing the amount of quinol formed, it increased the toxicity of menadione in the cells co-expressing both enzymes. | Hydroquinones | N-ribosyldihydronicotinamide:quinone reductase 2 | Homo sapiens |