Title : BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair.

Pub. Date : 2021 May 26

PMID : 34039959






1 Functional Relationships(s)
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1 Mechanistically, BKM120 decreased expression of HR molecules, including RAD51 and BRCA1/2, and reduced HR repair efficiency in GBM cells, therefore increasing levels of apoptosis induced by rucaparib. NVP-BKM120 BRCA1 DNA repair associated Homo sapiens