Title : Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways.

Pub. Date : 2021

PMID : 34025417






1 Functional Relationships(s)
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1 Further mechanistic studies showed that ibudilast administration inhibited the FA-induced upregulation of TLR4, blocked NF-kappaB nuclear translocation, and reduced the phosphorylation of NF-kappaB and IkappaBalpha, p38, ERK, and JNK. ibudilast nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus