Title : ΔN63 suppresses the ability of pregnancy-identified mammary epithelial cells (PIMECs) to drive HER2-positive breast cancer.

Pub. Date : 2021 May 22

PMID : 34023861






1 Functional Relationships(s)
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1 The underlying mechanism of these phenotypes seems to be a specific reduction of the tumor suppressor TAp63 isoform in p63+/- luminal cells, including PIMECs, with concomitant aberrant upregulation of the oncogenic DeltaNp63 isoform, as determined by qRT-PCR and scRNA-seq analyses. Phenobarbital tumor protein p63 Homo sapiens