Title : Identification of vitamin B6 as a PD-L1 suppressor and an adjuvant for cancer immunotherapy.

Pub. Date : 2021 Jul 5

PMID : 34023785






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 By using a metabolite library screen, we showed that pyridoxal (PL) significantly suppresses PD-L1 expression. Pyridoxal CD274 molecule Sus scrofa
2 By using a metabolite library screen, we showed that pyridoxal (PL) significantly suppresses PD-L1 expression. Pyridoxal CD274 molecule Sus scrofa
3 Functionally, PL enhances T cell killing activity by blocking the PD-1/PD-L1 signaling pathway. Pyridoxal CD274 molecule Sus scrofa
4 Thus, we have identified PL as an inhibitor of PD-L1, which provides a feasible option for combination immunotherapy. Pyridoxal CD274 molecule Sus scrofa