Title : Metabolomics Profiling of Patients With A-β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis.

Pub. Date : 2021 Aug

PMID : 34021044






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1 When stable and near-normoglycemic, "A-beta+" Ketosis-Prone Diabetes (KPD) patients manifest accelerated leucine catabolism and blunted ketone oxidation, which may underlie their proclivity to develop diabetic ketoacidosis (DKA).To understand metabolic derangements in A-beta+ KPD patients during DKA, we compared serum metabolomic profiles of adults during acute hyperglycemic crises, without (n=21) or with (n=74) DKA, and healthy controls (n=17). Leucine amyloid beta precursor protein Homo sapiens