Pub. Date : 2021
PMID : 34012878
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIM: To investigate the protective effect of heme oxygenase-1 (HO-1) against H2O2-induced apoptosis in human ARPE-19 cells. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 2 | AIM: To investigate the protective effect of heme oxygenase-1 (HO-1) against H2O2-induced apoptosis in human ARPE-19 cells. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 3 | METHODS: The lentiviral vector expressing HO-1 was prepared and transfected into apoptotic ARPE-19 cells induced by H2O2. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 4 | It was found that exogenous HO-1 significantly ameliorated H2O2-induced loss of cell viability, apoptosis and intracellular levels of reactive oxygen species (ROS) in ARPE-19 cells. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 5 | Furthermore, HO-1 upregulation further inhibited H2O2-induced release of cysteinyl aspartate specific proteinase-3 (caspase-3). | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |
| 6 | CONCLUSION: Exogenous HO-1 protect ARPE-19 cells against H2O2-induced oxidative stress by regulating the expressions of Nrf2, HO-1, Bcl-2, and caspase-3. | Hydrogen Peroxide | heme oxygenase 1 | Homo sapiens |