Title : Targeting histone deacetylase enhances the therapeutic effect of Erastin-induced ferroptosis in EGFR-activating mutant lung adenocarcinoma.

Pub. Date : 2021 Apr

PMID : 34012798






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, Vorinostat, a clinically used inhibitor targeting histone deacetylase, can robustly enhance the efficacy of ferroptosis inducers, leading to a dramatic increase of hydroperoxides in EGFR mutant lung cancer cells with intrinsic or acquired resistance to EGFR-TKI. Hydrogen Peroxide epidermal growth factor receptor Homo sapiens