Pub. Date : 2021
PMID : 34010445
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Firstly, the virus SARS-CoV-2 responsible for the Covid-19 infection uses an important renin-angiotensin system element - angiotensin-converting enzyme 2 (ACE2) - as a receptor protein for the entry into target cells and, in consequence, disturbs the function of the main (circulating) renin-angiotensin-aldosterone system (RAAS) and of the local renin-angiotensin system (RAS) localized in different tissues and organs. | Aldosterone | angiotensin converting enzyme 2 | Homo sapiens |
| 2 | The binding of SARS-CoV-2 to ACE2 leads to the down-regulation of this enzyme and, in the aftermath, to the excess of angiotensin II and aldosterone. | Aldosterone | angiotensin converting enzyme 2 | Homo sapiens |