Title : Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.

Pub. Date : 2021 Jun 10

PMID : 34009981






2 Functional Relationships(s)
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1 Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins. pyrimidine MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Here, we describe the design and synthesis of a series of pyrimidine-based derivatives able to inhibit Aurora A kinase activity and reduce levels of cMYC and MYCN. pyrimidine MYC proto-oncogene, bHLH transcription factor Homo sapiens