Pub. Date : 2022 Feb
PMID : 34003583
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The ERRalpha-VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR-CYP24A1-ERRalpha overexpression correlates with poor prognosis in patients with basal-like breast cancer. | Calcitriol | vitamin D receptor | Homo sapiens |
| 2 | Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol, the active form of vitamin D. | Calcitriol | vitamin D receptor | Homo sapiens |
| 3 | Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol, the active form of vitamin D. | Calcitriol | vitamin D receptor | Homo sapiens |
| 4 | Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol, the active form of vitamin D. | Calcitriol | vitamin D receptor | Homo sapiens |
| 5 | Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol, the active form of vitamin D. | Calcitriol | vitamin D receptor | Homo sapiens |
| 6 | We observed that ERRalpha functionally supported the proliferation of BC cell lines and acted as a calcitriol-induced regulator of VDR. | Calcitriol | vitamin D receptor | Homo sapiens |
| 7 | As such, ERRalpha deregulated the calcitriol-VDR transcription by enhancing the expression of CYP24A1 as well as of both ERalpha and aromatase (CYP19A1) in calcitriol-treated cells. | Calcitriol | vitamin D receptor | Homo sapiens |
| 8 | As such, ERRalpha deregulated the calcitriol-VDR transcription by enhancing the expression of CYP24A1 as well as of both ERalpha and aromatase (CYP19A1) in calcitriol-treated cells. | Calcitriol | vitamin D receptor | Homo sapiens |