Title : SARS-Cov-2 spike protein fragment 674-685 protects mitochondria from releasing cytochrome c in response to apoptogenic influence.

Pub. Date : 2021 Jul 5

PMID : 34000512






2 Functional Relationships(s)
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1 We demonstrate that SARS-Cov-2 spike protein peptide 674-685 competes with the antibody against 179-190 fragment of alpha7 nAChR subunit for the binding to alpha7-expressing cells and mitochondria and prevents the release of cytochrome c from isolated mitochondria in response to 0.5 mM H2O2 but does not protect intact U373 cells against apoptogenic effect of H2O2. Hydrogen Peroxide cytochrome c, somatic Homo sapiens
2 We demonstrate that SARS-Cov-2 spike protein peptide 674-685 competes with the antibody against 179-190 fragment of alpha7 nAChR subunit for the binding to alpha7-expressing cells and mitochondria and prevents the release of cytochrome c from isolated mitochondria in response to 0.5 mM H2O2 but does not protect intact U373 cells against apoptogenic effect of H2O2. Hydrogen Peroxide cytochrome c, somatic Homo sapiens