Title : Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus.

Pub. Date : 2021

PMID : 33995100






2 Functional Relationships(s)
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Protein Name
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1 Agents that increase cAMP have been suggested as alternative therapies, as this second messenger can inhibit the ERK cascade. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
2 This suggests that sustained elevation of cAMP in the nucleus is necessary for efficient inhibition of PDGF-induced nuclear ERK and fibroblast proliferation. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens