Pub. Date : 2021
PMID : 33995081
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Imatinib is transported extracellularly by ABCB1 and ABCG2 efflux transporters and bound to alpha-1-acid glycoprotein (AGP) in the bloodstream. | Imatinib Mesylate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | However, the clinical and pharmacokinetic effects of ABCB1 and ABCG2 on imatinib were inconsistent in the previous literature and have not been confirmed. | Imatinib Mesylate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Therefore, in the present study, we explored the effects of the ABCG2 and ABCB1 genetic polymorphisms on imatinib pharmacokinetics in association with plasma AGP levels in healthy subjects. | Imatinib Mesylate | ATP binding cassette subfamily B member 1 | Homo sapiens |