Pub. Date : 2021
PMID : 33995066
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Boosting Akt Pathway by Rupatadine Modulates Th17/Tregs Balance for Attenuation of Isoproterenol-Induced Heart Failure in Rats. | rupatadine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | It also explored the role of PI3k/Akt as a possible mechanistic pathway, through which rupatadine could modulate Th17/Tregs balance to display its effect. | rupatadine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | Rupatadine treatment mitigated isoproterenol-induced activation of STAT-3 signaling and the imbalance in p-Akt/total Akt ratio affording marked decrease in atrogin-1 and apoptotic biomarkers. | rupatadine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | Rupatadine treatment mitigated isoproterenol-induced activation of STAT-3 signaling and the imbalance in p-Akt/total Akt ratio affording marked decrease in atrogin-1 and apoptotic biomarkers. | rupatadine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 5 | In conclusion, rupatadine could be an effective therapy against the development of isoproterenol-induced heart failure where PI3K/Akt pathway seems to play a crucial role in its protective effect. | rupatadine | AKT serine/threonine kinase 1 | Rattus norvegicus |