Title : Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol-dependent cytolysins.

Pub. Date : 2021 Jun

PMID : 33991130






2 Functional Relationships(s)
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1 The bisphosphonates were then screened for their ability to protect HeLa cells against the damage caused by the cholesterol-dependent cytolysin, pyolysin. Diphosphonates perforin 1 Homo sapiens
2 The bisphosphonate also protected cells against another cholesterol-dependent cytolysin, streptolysin O, and protected lung epithelial cells and primary dermal fibroblasts against cytolysis. Diphosphonates perforin 1 Homo sapiens