Title : (-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells.

Pub. Date : 2021 Jul

PMID : 33989703






1 Functional Relationships(s)
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1 Both (-)-epicatechin and (+)-catechin were effective competitors of [3H]-testosterone binding to PC-3 prostate cancer cells (nuclear androgen receptor-negative, nAR-null) overexpressing ZIP9 (PC3-ZIP9), with relative binding affinities of 75% and 28% that of testosterone, respectively. Testosterone androgen receptor Homo sapiens