Pub. Date : 2021 Jul
PMID : 33987937
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross-talk with p53 to activate p21. | Lovastatin | H3 histone pseudogene 16 | Homo sapiens |
| 2 | At molecular level, Lovastatin by dephosphorylating STAT3, induced ERK1/2 activation that inhibited autophagy and phosphorylated p53ser15 that in turn maintained ERK1/2 activated and up-regulated p21. | Lovastatin | H3 histone pseudogene 16 | Homo sapiens |
| 3 | However, p21 played a pro-survival role in this setting, as its inhibition by UC2288 further reduced cell survival in PEL cells undergoing Lovastatin treatment. | Lovastatin | H3 histone pseudogene 16 | Homo sapiens |
| 4 | In conclusion, this study suggests that Lovastatin may represent a valid therapeutic alternative against PEL cells, especially if used in combination with p21 inhibitors. | Lovastatin | H3 histone pseudogene 16 | Homo sapiens |