Title : Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture.

Pub. Date : 2021 May 18

PMID : 33984267






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HCV drugs that inhibit PLpro synergize with the viral polymerase inhibitor remdesivir to inhibit virus replication, increasing remdesivir"s antiviral activity as much as 10-fold, while those that only inhibit Mpro do not synergize with remdesivir. remdesivir ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2
2 HCV drugs that inhibit PLpro synergize with the viral polymerase inhibitor remdesivir to inhibit virus replication, increasing remdesivir"s antiviral activity as much as 10-fold, while those that only inhibit Mpro do not synergize with remdesivir. remdesivir ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2