Pub. Date : 2021 May
PMID : 33983927
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. | polyglutamine | Receptor of activated protein kinase C 1 | Drosophila melanogaster |
| 2 | Loss of the scaffold protein RACK1 alleviated cell death associated with the expression of polyQ tracts alone, as well as in models of Machado-Joseph disease (MJD) and Huntington"s disease (HD), without affecting proteostasis of polyQ proteins. | polyglutamine | Receptor of activated protein kinase C 1 | Drosophila melanogaster |
| 3 | Loss of the scaffold protein RACK1 alleviated cell death associated with the expression of polyQ tracts alone, as well as in models of Machado-Joseph disease (MJD) and Huntington"s disease (HD), without affecting proteostasis of polyQ proteins. | polyglutamine | Receptor of activated protein kinase C 1 | Drosophila melanogaster |
| 4 | A genome-wide RNAi screen for modifiers of this rack1 suppression phenotype revealed that knockdown of the E3 ubiquitin ligase, POE (Purity of essence), further suppressed polyQ-induced cell death, resulting in nearly wild-type looking eyes. | polyglutamine | Receptor of activated protein kinase C 1 | Drosophila melanogaster |
| 5 | These results suggest that RACK1 plays a key role in polyQ pathogenesis by promoting POE-dependent degradation of ERK, and implicate RACK1/POE/ERK as potent drug targets for treatment of polyQ diseases. | polyglutamine | Receptor of activated protein kinase C 1 | Drosophila melanogaster |