Title : Metformin acts to suppress β-hydroxybutyric acid-mediated inflammatory responses through activation of AMPK signaling in bovine hepatocytes.

Pub. Date : 2021 Jul 1

PMID : 33982074






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1 Compared to BHBA treated cells, the protein expression of COX-2 and IL-1beta were decreased by the pretreatment with metformin, and the inhibitory effect of metformin was released by compound C. The bound of NF-kappaB onto IL1B promoter displayed higher in BHBA group and this was suppressed by pretreatment with metformin (P < 0.05). 3-Hydroxybutyric Acid interleukin 1 beta Bos taurus