Title : Switching the Proteolytic System from the Ubiquitin-Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model.

Pub. Date : 2021 Jul 1

PMID : 33974963






1 Functional Relationships(s)
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1 Treatment with MG132 or 3MA significantly increased the clinical hanging wire score and exacerbated alpha-motor neuron loss at 18 weeks in G93A mice, and increased the amount of ubiquitin, p62 aggregates, and BAG3 expression. 3-methyladenine nucleoporin 62 Mus musculus