Title : A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice.

Pub. Date : 2021 May 4

PMID : 33972944






1 Functional Relationships(s)
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1 This demonstrates that TTSP-mediated proteolytic maturation of spike is critical for SARS-CoV-2 infection in vivo and suggests that N-0385 provides a novel effective early treatment option against COVID-19 and emerging SARS-CoV-2 VOCs. Ms-QFR-Kbt surface glycoprotein Severe acute respiratory syndrome coronavirus 2