Pub. Date : 2022 Jan
PMID : 33971703
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enrichment of Wee1/CDC2 and NF-kappaB Signaling Pathway Constituents Mutually Contributes to CDDP Resistance in Human Osteosarcoma. | Cisplatin | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Although the Wee1/CDC2 and NF-kappaB pathways were reported to show abnormal activation in some tumor cells with CDDP resistance, whether there is any concrete connection is currently unclear. | Cisplatin | cyclin dependent kinase 1 | Homo sapiens |
| 3 | In the highly CDDP-tolerant cell lines, Wee1 and RelA were physically crosslinked, which resulted in increased abundance of phosphorylated CDC2 (Y15) and RelA (S536) and consequent modulation of cell cycle progression, survival and proliferation. | Cisplatin | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Conclusion: Simultaneous enrichment of molecules in the Wee1/CDC2 and NF-kappaB pathways and their consequent coactivation is a new molecular mechanism of CDDP resistance in OS cells. | Cisplatin | cyclin dependent kinase 1 | Homo sapiens |