Title : LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species.

Pub. Date : 2021 Jul

PMID : 33971543






1 Functional Relationships(s)
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1 LPS reduced cystic fibrosis transmembrane conductance regulater (CFTR)-mediated short-circuit current in mammalian REC in Ussing chambers and nearly abrogated CFTR single channel activity (defined as forskolin-activated Cl- currents) in patch clamp studies, effects of which were blocked with toll-like receptor (TLR)-4 inhibitor. Colforsin CF transmembrane conductance regulator Homo sapiens