Title : Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors.

Pub. Date : 2021 Jun 15

PMID : 33971490






1 Functional Relationships(s)
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1 Mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are located at the meeting-point of ERK and p38 MAPK signaling pathways, which can phosphorylate eukaryotic translation initiation factor 4E (eIF4E) at the conserved serine 209 exclusively. Serine mitogen-activated protein kinase 1 Homo sapiens