Title : Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB, and TBCE.

Pub. Date : 2021

PMID : 33968934






1 Functional Relationships(s)
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1 The anti-inflammatory action of colchicine seems to result from irreversible inhibition of tubulin polymerization and microtubule (MT) assembly by binding to the tubulin heterodimer, avoiding the signal transduction required to the activation of the entire NLRP3 inflammasome. Colchicine NLR family pyrin domain containing 3 Homo sapiens