Title : Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris.

Pub. Date : 2021

PMID : 33968042






6 Functional Relationships(s)
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1 Cells treated with hydrogen peroxide also exhibited augmented nuclear YAP accompanied by reduction of Dsg3 and alpha-catenin, a negative regulator of YAP. Hydrogen Peroxide Yes1 associated transcriptional regulator Homo sapiens
2 Cells treated with hydrogen peroxide also exhibited augmented nuclear YAP accompanied by reduction of Dsg3 and alpha-catenin, a negative regulator of YAP. Hydrogen Peroxide Yes1 associated transcriptional regulator Homo sapiens
3 As expected, transfection of alpha-catenin-GFP plasmid rendered YAP export from the nucleus evoked by hydrogen peroxide. Hydrogen Peroxide Yes1 associated transcriptional regulator Homo sapiens
4 In addition, suppression of total YAP was observed in hydrogen peroxide treated cells exposed to antioxidants with enhanced cell-cell adhesion being confirmed by decreased fragmentation in the dispase assay compared to hydrogen peroxide treatment alone. Hydrogen Peroxide Yes1 associated transcriptional regulator Homo sapiens
5 In addition, suppression of total YAP was observed in hydrogen peroxide treated cells exposed to antioxidants with enhanced cell-cell adhesion being confirmed by decreased fragmentation in the dispase assay compared to hydrogen peroxide treatment alone. Hydrogen Peroxide Yes1 associated transcriptional regulator Homo sapiens
6 Finally, inhibition of other kinase pathways, including p38MAPK, also demonstrated suppression of YAP induced by hydrogen peroxide. Hydrogen Peroxide Yes1 associated transcriptional regulator Homo sapiens