Pub. Date : 2021 Aug
PMID : 33965440
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: P-glycoprotein (P-gp) is a prevalent resistance mediator and it requires considerable cellular energy to ensure ATP dependent efflux of anticancer drugs. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: P-glycoprotein (P-gp) is a prevalent resistance mediator and it requires considerable cellular energy to ensure ATP dependent efflux of anticancer drugs. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The glycolytic pathway generates the majority of catabolic energy in cancer cells; however, the high rates of P-gp activity places added strain on its inherently limited capacity to generate ATP. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | This is particularly relevant for compounds such as verapamil that are believed to trap P-gp in a futile transport process that requires continuing ATP consumption. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Even in the absence of verapamil, P-gp expressing cells display near maximal rates of glycolysis and oxidative phosphorylation, which prevents an adequate response to the demand for ATP to sustain transport activity. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | CONCLUSIONS: Our results demonstrate that the strained metabolic profiles of P-gp expressing resistant cancer cells can be overwhelmed by additional ATP demands. | Adenosine Triphosphate | ATP binding cassette subfamily B member 1 | Homo sapiens |