Title : Voluntary wheel-running exercise attenuates brain aging of rats through activating miR-130a-mediated autophagy.

Pub. Date : 2021 Jul

PMID : 33964346






2 Functional Relationships(s)
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1 Moreover, overexpression of miR-130a in D-galactose (D-gal)-induced SH-SY5Y cell senescence model attenuated D-gal-induced impaired autophagy and cell senescence, demonstrated by decreased levels of LC3, Ac-p53, p21 and increased p62, suggesting that voluntary wheel running can alleviate brain aging in natural aging rats by up-regulating miR-130a-mediated autophagy. Galactose tumor protein p53 Homo sapiens
2 Moreover, overexpression of miR-130a in D-galactose (D-gal)-induced SH-SY5Y cell senescence model attenuated D-gal-induced impaired autophagy and cell senescence, demonstrated by decreased levels of LC3, Ac-p53, p21 and increased p62, suggesting that voluntary wheel running can alleviate brain aging in natural aging rats by up-regulating miR-130a-mediated autophagy. Galactose tumor protein p53 Homo sapiens