Pub. Date : 2021 Dec
PMID : 33963573
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects. | Enalapril | carboxylesterase 1 | Homo sapiens |
| 2 | BACKGROUND AND OBJECTIVE: Enalapril is a prodrug and needs to be activated by carboxylesterase 1 (CES1). | Enalapril | carboxylesterase 1 | Homo sapiens |
| 3 | BACKGROUND AND OBJECTIVE: Enalapril is a prodrug and needs to be activated by carboxylesterase 1 (CES1). | Enalapril | carboxylesterase 1 | Homo sapiens |
| 4 | A previous in vitro study demonstrated the CES1 genetic variant, G143E (rs71647871), significantly impaired enalapril activation. | Enalapril | carboxylesterase 1 | Homo sapiens |
| 5 | A prospective, multi-dose, pharmacokinetics, and pharmacodynamics (PK/PD) study was conducted to determine the impact of the CES1 G143E variant on enalapril steady-state PK and PD in healthy volunteers. | Enalapril | carboxylesterase 1 | Homo sapiens |
| 6 | CONCLUSIONS: The CES1 loss-of-function G143E variant significantly impaired enalapril activation and its systolic blood pressure-lowering effect in healthy volunteers. | Enalapril | carboxylesterase 1 | Homo sapiens |