Title : Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway.

Pub. Date : 2021 Jun 15

PMID : 33961948






3 Functional Relationships(s)
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1 In this study, we hypothesized that tumour necrosis factor-alpha (TNF-alpha), a key mediator of inflammation, modulates BaP- and PhIP-induced DNA damage in colon cancer epithelial cells. Benzo(a)pyrene tumor necrosis factor Homo sapiens
2 Importantly, we observed that TNF-alpha alone (0.1 to 100 pg/ml) induced DNA damage (micronuclei formation) in HCT-116 cells and co-treatment of TNF-alpha with BaP or PhIP showed higher levels of DNA damage compared to the individual single treatments. Benzo(a)pyrene tumor necrosis factor Homo sapiens
3 Importantly, we observed that TNF-alpha alone (0.1 to 100 pg/ml) induced DNA damage (micronuclei formation) in HCT-116 cells and co-treatment of TNF-alpha with BaP or PhIP showed higher levels of DNA damage compared to the individual single treatments. Benzo(a)pyrene tumor necrosis factor Homo sapiens