Title : p70S6K on astrocytes protects dopamine neurons from 1-methyl-4-phenylpyridinium neurotoxicity.

Pub. Date : 2021 Sep

PMID : 33956370






1 Functional Relationships(s)
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1 Administration of a TRPV1 agonist, capsaicin, increases levels of phosphorylated p70S6K (p-p70S6K; activation of p70S6K) on astrocytes, resulting in the survival of dopamine neurons and behavioral recovery through endogenous production of CNTF in the MPP+ -lesioned rat model of PD. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus