Pub. Date : 2021
PMID : 33954150
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Priming Leukemia with 5-Azacytidine Enhances CAR T Cell Therapy. | Azacitidine | nuclear receptor subfamily 1 group I member 3 | Homo sapiens |
| 2 | Priming leukemia cells with AZA increased CAR T cell/target cell conjugation and target cell killing, promoted CAR T cell divisions and expanded IFNgamma+ effector T cells in co-cultures with CD19+ leukemia Nalm-6 and Raji cells. | Azacitidine | nuclear receptor subfamily 1 group I member 3 | Homo sapiens |
| 3 | Priming leukemia cells with AZA increased CAR T cell/target cell conjugation and target cell killing, promoted CAR T cell divisions and expanded IFNgamma+ effector T cells in co-cultures with CD19+ leukemia Nalm-6 and Raji cells. | Azacitidine | nuclear receptor subfamily 1 group I member 3 | Homo sapiens |
| 4 | Conclusion: We propose that treatment with AZA activates OX40L/OX40 co-stimulatory signaling in CAR T cells. | Azacitidine | nuclear receptor subfamily 1 group I member 3 | Homo sapiens |