Title : Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore.

Pub. Date : 2021 Apr 27

PMID : 33953843






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we show that mibefradil inhibits DNA repair independent of its CCB activity, and report a series of mibefradil analogues which lack CCB activity and demonstrate reduced hERG and CYP activity while retaining potency as DNA repair inhibitors. Mibefradil ETS transcription factor ERG Homo sapiens