Title : Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.

Pub. Date : 2021 May 5

PMID : 33953191






2 Functional Relationships(s)
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1 These G4s locally perturb replisome dynamics and organization by reducing DNA synthesis and limiting the binding of the single-strand DNA-binding protein RPA. Dichlorophen replication protein A1 Homo sapiens
2 We find that the resolution of RF-coupled G4s is mediated by an interplay between RPA and the FANCJ helicase. Dichlorophen replication protein A1 Homo sapiens