Pub. Date : 2021 May 7
PMID : 33950972
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Azathioprine-induced toxoplasma gondii infection in a patient with Crohn"s disease with NUDT15 variation: A case report. | Azathioprine | nudix hydrolase 15 | Homo sapiens |
| 2 | Most of the previous literature focused on the TPMP gene-related adverse reactions, herein, we report a case of Crohn"s disease patient with nucleoside diphosphate-linked moiety X motif 15 gene (NUDT15) variation and wild-type TPMP gene who developed toxoplasma gondii infection after azathioprine treatment. | Azathioprine | nudix hydrolase 15 | Homo sapiens |
| 3 | CONCLUSION: We report a case of Crohn"s disease in a patient who developed severe pneumonia caused by toxoplasma gondii infection due to the administration of AZA, with normal TPMP gene but NUDT15 gene mutation. | Azathioprine | nudix hydrolase 15 | Homo sapiens |
| 4 | This indicates that NUDT15 variation may contribute to severe adverse events in patients treated with azathioprine, and we suggest that NUDT15 genotype be detected before the use of azathioprine in order to provide personalized therapy and reduce side effects. | Azathioprine | nudix hydrolase 15 | Homo sapiens |