Title : Inhibition of endothelial cell retraction by ATP depletion.

Pub. Date : 1988 Jul

PMID : 3394800






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Monolayers exposed to histamine showed a retraction of the dense peripheral band of actin to a subcortical position. Histamine actin epsilon 1 Bos taurus
2 ECV or histamine induced a small reduction in F-actin content while cyto B resulted in a 50% decline in 15 minutes. Histamine actin epsilon 1 Bos taurus
3 These studies indicate that ATP is essential for changes in actin filament distribution and endothelial cell retraction produced by ECV, histamine or cyto B, and make it unlikely that any of these agents acts simply by depolymerization of actin filaments or modification of the dense peripheral band, although disruption of the dense peripheral band may facilitate retraction in the presence of adequate levels of cell ATP. Histamine actin epsilon 1 Bos taurus