Pub. Date : 1988 Aug
PMID : 3394155
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acute and subacute effects of miconazole nitrate on hepatic styrene oxide hydrolase and cytochrome P-450-dependent monooxygenase activities in male and female AKR/J mice. | Miconazole | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 2 | The imidazole-containing anti-fungal drug, miconazole nitrate, was shown to enhance hepatic microsomal styrene oxide hydrolase and inhibit several cytochrome P-450-dependent monooxygenase activities in the AKR/J mouse. | Miconazole | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Miconazole was a more potent inhibitor of cytochrome P-450-dependent monooxygenase activities in microsomes from male than female mice, and inhibitory potency also varied with substrate. | Miconazole | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 4 | When administered in vivo miconazole nitrate stimulated epoxide hydrolase activity, but had a substrate-dependent biphasic effect on cytochrome P-450-dependent monooxygenase activities. | Miconazole | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |
| 5 | After repeated administration of miconazole, liver weight, microsomal protein yield and cytochrome P-450 were increased, as were specific monooxygenase activities with ethoxycoumarin and ethoxyresorufin, but benzphetamine N-demethylase activity was decreased. | Miconazole | cytochrome P450, family 21, subfamily a, polypeptide 1 | Mus musculus |